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Pakistani Pharma Guide 2011 Pdf: Product Strategies and Marketing Tips for Pharmaceutical Products i



Up to Date: 2 weeks after 3rd dose; there is not a recommendation for an updated (bivalent) Pfizer-BioNTech booster for this age groupMore details: Staying up to date


Novavax booster: You may get a monovalent Novavax booster if you are unable or unwilling to receive a Pfizer or Moderna updated (bivalent) COVID-19 booster and you meet the following requirements:




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In October 2021, the FATF updated its 2019 Guidance for a Risk-Based Approach to Virtual Assets and Virtual Asset Service Providers (VASPs).RBA for Virtual Assets & Virtual Asset Service ProvidersUpdated Guidance for a Risk-Based Approach for Virtual Assets and Virtual Asset Service Providers


This section was originally issued on December 16, 2020, and was updated on October 25, 2021 and July 12, 2022. Note that the Centers for Disease Control and Prevention (CDC) has issued guidance for vaccinated individuals that addresses, among other things, when they need to wear a mask indoors.


Abstract. Although now over 100 years old, the classification of climate originally formulated by Wladimir Köppen and modified by his collaborators and successors, is still in widespread use. It is widely used in teaching school and undergraduate courses on climate. It is also still in regular use by researchers across a range of disciplines as a basis for climatic regionalisation of variables and for assessing the output of global climate models. Here we have produced a new global map of climate using the Köppen-Geiger system based on a large global data set of long-term monthly precipitation and temperature station time series. Climatic variables used in the Köppen-Geiger system were calculated at each station and interpolated between stations using a two-dimensional (latitude and longitude) thin-plate spline with tension onto a 0.10.1 grid for each continent. We discuss some problems in dealing with sites that are not uniquely classified into one climate type by the Köppen-Geiger system and assess the outcomes on a continent by continent basis. Globally the most common climate type by land area is BWh (14.2%, Hot desert) followed by Aw (11.5%, Tropical savannah). The updated world Köppen-Geiger climate map is freely available electronically in the Supplementary Material Section.


The objective of this paper is to describe the updated methodological guidance for conducting a JBI scoping review, with a focus on new updates to the approach and development of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (the PRISMA-ScR).


Scoping reviews are an increasingly common approach to informing decision-making and research based on the identification and examination of the literature on a given topic or issue. Scoping reviews draw on evidence from any research methodology and may also include evidence from non-research sources, such as policy. In this manner, scoping reviews provide a comprehensive overview to address broader review questions than traditionally more specific systematic reviews of effectiveness or qualitative evidence. The increasing popularity of scoping reviews has been accompanied by the development of a reporting guideline: the PRISMA-ScR. In 2014, the JBI Scoping Review Methodology Group developed guidance for scoping reviews that received minor updates in 2017 and was most recently updated in 2020. The updates reflect ongoing and substantial developments in approaches to scoping review conduct and reporting. As such, the JBI Scoping Review Methodology Group recognized the need to revise the guidance to align with the current state of knowledge and reporting standards in evidence synthesis.


Between 2015 and 2020, the JBI Scoping Review Methodology Group expanded its membership; extensively reviewed the literature; engaged via annual face-to-face meetings, regular teleconferences, and email correspondence; sought advice from methodological experts; facilitated workshops; and presented at scientific conferences. This process led to updated guidance for scoping reviews published in the JBI Manual for Evidence Synthesis. The updated chapter was endorsed by JBI's International Scientific Committee in 2020.


The updated JBI guidance for scoping reviews includes additional guidance on several methodological issues, such as when a scoping review is (or is not) appropriate, and how to extract, analyze, and present results, and provides clarification for implications for practice and research. Furthermore, it is aligned with the PRISMA-ScR to ensure consistent reporting.


A. The HWB Program Portal will be updated regularly with program updates and/or the most up to date information for employers. Please also visit the eMedNY listServ page to subscribe to applicable listServs.


CDC has also updated its guidance for COVID-19 prevention in K-12 schools to recommend universal indoor masking for all teachers, staff, students, and visitors to K-12 schools, regardless of vaccination status.3 CDC's Face Mask Order requiring masks on public transportation conveyances and inside transportation hubs has not changed, but CDC has announced that it will be amending its Face Masks Order to not require people to wear a mask in outdoor areas of conveyances (if such outdoor areas exist on the conveyance) or while outdoors at transportation hubs, and that it will exercise its enforcement discretion in the meantime.


CDC's Interim Public Health Recommendations for Fully Vaccinated People explains that under some circumstances, fully vaccinated people need not take all the precautions that unvaccinated people should take, except where required by federal, state, local, tribal, or territorial laws, rules and regulations, including local business and workplace guidance. However, in light of evidence related to the Delta variant of the SARS-CoV-2 virus, the CDC updated its guidance to recommend that even people who are fully vaccinated wear a mask in public indoor settings in areas of substantial or high transmission, or if they have had a known exposure to someone with COVID-19 and have not had a subsequent negative test 3-5 days after the last date of that exposure. Schools should continue to follow applicable CDC guidance, which recommends universal indoor masking for all teachers, staff, students, and visitors to K-12 schools, regardless of vaccination status.


Two classification schemes for beta-lactamases are currently in use. The molecular classification is based on the amino acid sequence and divides beta-lactamases into class A, C, and D enzymes which utilize serine for beta-lactam hydrolysis and class B metalloenzymes which require divalent zinc ions for substrate hydrolysis. The functional classification scheme updated herein is based on the 1995 proposal by Bush et al. (K. Bush, G. A. Jacoby, and A. A. Medeiros, Antimicrob. Agents Chemother. 39:1211-1233, 1995). It takes into account substrate and inhibitor profiles in an attempt to group the enzymes in ways that can be correlated with their phenotype in clinical isolates. Major groupings generally correlate with the more broadly based molecular classification. The updated system includes group 1 (class C) cephalosporinases; group 2 (classes A and D) broad-spectrum, inhibitor-resistant, and extended-spectrum beta-lactamases and serine carbapenemases; and group 3 metallo-beta-lactamases. Several new subgroups of each of the major groups are described, based on specific attributes of individual enzymes. A list of attributes is also suggested for the description of a new beta-lactamase, including the requisite microbiological properties, substrate and inhibitor profiles, and molecular sequence data that provide an adequate characterization for a new beta-lactam-hydrolyzing enzyme.


The resulting database and online tools enable comparison of water-related risks across large geographies to identify regions or assets deserving of closer attention. Aqueduct 3.0 introduces an updated water risk framework and new and improved indicators. It also features different hydrological sub-basins. We introduce indicators based on a new hydrological model that now features (1) integrated water supply and demand, (2) surface water and groundwater modeling, (3) higher spatial resolution, and (4) a monthly time series that enables the provision of monthly scores for selected indicators.


The updated criteria take effect on Wednesday 15 June 2022. New applicants are required to adopt these strengthened criteria immediately to join the campaign. Existing Partners and members will need to meet the new criteria by 15th June 2023 at the latest.


On June 15, 2022, EPA issued interim updated drinking water health advisories for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) that replace those EPA issued in 2016. PFOA and PFOS are members of a chemical group called per- and polyfluoroalkyl substances (PFAS). The updated advisory levels, which are based on new science and consider lifetime exposure, indicate that some negative health effects may occur with concentrations of PFOA or PFOS in water that are near zero. These interim health advisories will remain in place until EPA establishes a National Primary Drinking Water Regulation.


Sea ice data is updated daily, with a one-day lag. The orange line in extent and concentration images (left and middle) and the gray line in the time series (right) indicate 1981 to 2010 average extent for the day shown. The graph also includes lines for selected earlier years, for comparison. Learn about update delays and other problems which occasionally occur in near-real-time data. Read about the data.


Update on recommendations on antiretroviral regimens for treating and preventing HIV infection: In 2016, WHO published the consolidated guidelines on the use of antiretroviral (ARV) drugs for treating and preventing HIV infection and recommended tenofovir disoproxil fumarate (TDF) + lamivudine (3TC) (or emtricitabine, FTC) + efavirenz (EFV) 600 mg as the preferred first- line antiretroviral therapy (ART) regimen for adults and adolescents. Since that time, scientific evidence and programmatic experience have accumulated on the use of dolutegravir (DTG) in both first- and second-line ART, including during pregnancy and tuberculosis co-treatment, and for children. In 2018, these guidelines were reviewed to provide updated guidance on preferred option for these populations which now include DTG and raltegravir (RAL), and updated recommendations on using ARV drugs for HIV post-exposure prophylaxis. Annex 3 above links to the ARV dosing guidance for children, adolescents and adults. 2ff7e9595c


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